Null the Void
Start your run with Potion of Sourcery, Soul Sieve and the Null the Void Artifacts.Artifacts
Potion of SourceryGain 1 class-specific potion after you win your next battle.
Drinking any potion restores 8 HP. The 8th time this triggers, heal an additional 8 and the potion isn't consumed.
Soul SieveGain 1 extra Soul after every battle.
Null the VoidThe Void will have 1,000% baseline HP. Hope you have a hundred souls... or a very good deck.