Start your run with Spirit Flail, Crystal Lake Hand-me-down and the Heavy Mettle Artifacts.
Artifacts
Spirit FlailThe first Attack played each turn has Discharge 1: Ghost.
Crystal Lake Hand-me-downEvery 3rd Heavy card played will cost -3. The first time each Battle you play a Heavy card, Upgrade it and add a Red Void Stone to it.
Heavy MettleNon-heavy Attacks instead apply Shock equal to the damage they would've dealt. They no longer benefit from Shock, Rage or Vulnerable themselves.